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Berberine Plus by OTS is a formula backed by extensive clinical research and designed to address several factors associated with ideal cardiometabolic health. Berberine Plus (with ALA) is OTS's powerful combination of berberine and alpha lipoic acid (ALA) formulated to support healthy lipid and glucose leveles, metabolism, and help maintain heart function. Berberine Plus (with ALA) supportst for cardiovascular health by enhancing cell signaling for efficient ATP production, maintaining healthy cholesterol levels, and supporting blood sugar balance already within normal levels. Berberine Plus provides a powerful combination supplement for those looking for support for many mechanisms of cardiovascular and metabolic health

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  • Berberine supports healthy blood pressure.
  • It supports healthy blood sugar levels.
  • Berberine helps support a healthy lipid profile
  • Helps to reduce brain damage that occurs after a stroke.
  • Has anti-inflammatory activity which helps reduces bone deterioration.

The three conditions for which berberine is most often used are diabetes, high blood pressure, and excessive cholesterol or other blood fat levels. It is also used to burns, canker sores, liver illness, and many other ailments, although many of these applications need strong scientific backing.

The master regulator of cellular energy homeostasis, adenosine monophosphate-activated protein kinase (AMPK), which is involved in various biological processes, including the control of glucose, lipids , and protein metabolism, appears to be the primary mechanism by which berberine exerts its effects.

People with diabetes who receive 600–1800 mg of alpha-lipoic acid intravenously or orally report fewer sensations of burning, discomfort, and numbness in their legs and arms. Alpha-lipoic acid is not effective at lower levels.

In patients with and without hyperlipidemia, oral administration of alpha-lipoic acid for up to 4 years decrease total cholesterol and low-density lipoprotein (LDL or "bad") cholesterol. Adults who are overweight lower their body weight by taking oral alpha-lipoic acid.

Oral treatment with 0.9 grams of berberine daily decreases blood pressure more efficiently in individuals with high blood pressure than the oral administration of amlodipine alone.

A hormonal disorder that causes bigger, cyst-filled ovaries (polycystic ovary syndrome or PCOS). Oral berberine may benefit PCOS patients' testosterone, waist-to-hip ratio, blood sugar, cholesterol, and triglycerides levels.

The antioxidant properties of ALA have been linked to various benefits, including lowered blood sugar levels, reduced inflammation, enhanced cardiovascular health, postponed skin ageing, and improved neuron function.

Berberine and alpha lipoic acid (ALA) is a potent duo that supports healthy lipid and glucose levels, heart health, and metabolism. In addition to lipid balance, other metabolic processes that contribute to cardiovascular health include blood sugar regulation, blood pressure regulation, and inflammatory equilibrium.

Berberine and alpha-lipoic acid have several positive effects, one of which is the activation of adenosine monophosphate kinase (AMPK). This potent metabolic enzyme, when activated, sets off a cascade of genes that aid in metabolic improvement, mitochondrial stability, and insulin sensitivity. Support for blood sugar, lipid balance, inflammatory balance, enhanced metabolism, and antioxidant status have all been shown to be essential in promoting cardiovascular health in clinical studies. The innovative mix used in Berberine Plus provides a multifaceted aid for cardiovascular health.


    Alpha Lipoic Acid (ALA)

  • This antioxidant, both produced naturally and present in food, helps turn glucose into energy. Antioxidants fight against "free radicals," waste products of food's transformation into energy. Free radicals harm cells by triggering unfavorable chemical reactions and impair the body's disease-fighting ability.
  • Red meat, carrots, beets, spinach, broccoli, and potatoes contain alpha-lipoic acid. Additionally, it is offered as a supplement. Alpha-lipoic acid may protect the brain and help treat certain liver illnesses since it functions as an antioxidant.
  • Alpha-lipoic acid is useful in supporting patients with nerve discomfort, in people with diabetes, obesity, altitude sickness, aged skin, high cholesterol levels, etc.


  • Barberry, Oregon grape, and tree turmeric contain the alkaloid berberine.
  • Ayurvedic and traditional Chinese medicine have utilized it as an antibacterial, antiprotozoal, and antidiarrheal drug.
  • Clinical trials have studied how berberine affects anthropometric factors, blood lipids, liver function indicators, and markers of glycemic management in metabolic diseases.
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